{"id":6767,"date":"2022-04-29T00:48:13","date_gmt":"2022-04-28T15:48:13","guid":{"rendered":"https:\/\/abionbio.com\/?page_id=6767"},"modified":"2024-05-13T21:00:37","modified_gmt":"2024-05-13T12:00:37","slug":"abn201","status":"publish","type":"page","link":"https:\/\/abionbio.com\/en\/abn201\/","title":{"rendered":"ABN201"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”20px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”advanced” shape_type=”” advanced_gradient_display_type=”linear”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin=”0″ column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default” column_padding_type=”default”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7371″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”BEST-IN-CLASS cMET TKI For NSCLC Patient” link_url=”\/en\/abn401\/” min_height=”250″ min_height_phone=”175″]\n

ABN401<\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7369″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”Broad Spectrum Prophylaxis
\nAnti-viral Inhaler Therapeutics” link_url=”\/en\/abn101\/” min_height=”250″ min_height_phone=”175″]\n

ABN101<\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7370″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”Pan-Carcinoma Target Drug” link_url=”\/en\/abn501\/” min_height=”250″ min_height_phone=”175″]\n

ABN501<\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7366″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” link_url=”\/en\/abn201\/” min_height=”250″ min_height_phone=”175″ hover_content=”Pioneering Antibody Cytokine Fusion Protein Platform”]\n

ABN201<\/h3>\n[\/fancy_box][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”130PX” bottom_margin=”0″ column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][nectar_highlighted_text color_type=”regular” highlight_color=”#c2e3ea” style=”half_text” delay=”100″]\n

ABN201 <\/b><\/em>is an antibody cytokine fusion protein(ACFP) which adds antibody targeting ability to ABN101 with effective anticancer activity. It has a potential to be developed as an anticancer platform with greater application than ADC. ABN201 is targeting solid cancer and combination therapy with ABN401 and EGFR inhibitors are being studied. <\/span><\/h4>\n[\/nectar_highlighted_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin=”80px” column_element_direction_desktop=”default” column_element_spacing=”default” centered_text=”true” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][image_with_animation image_url=”6966″ image_size=”full” animation_type=”entrance” animation=”Fade In” animation_easing=”default” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default” margin_top=”40px”][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” bottom_padding=”150px” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”100PX” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][vc_column_text]\n

Anticancer mechanisms of action of antibody-IFN\u03b2 mutein fusion protein<\/b><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”10px”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-4-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][split_line_heading animation_type=”line-reveal-by-space” font_style=”h4″ text_color=”#31a7b1″ line_reveal_by_space_text_effect=”default” stagger_animation=”true” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”Direct Cytotoxicity<\/b>” max_width=”500″][\/split_line_heading][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-3″ animate=”yes” delay=”100″][divider line_type=”No Line” custom_height=”10px”][image_with_animation image_url=”6931″ image_size=”full” animation_type=”entrance” animation=”Fade In” animation_easing=”default” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”]
\n
    \n
  • IFNb localization to tumor<\/li>\n
  • Direct tumor cell killing through IFN-receptor induced death receptor mediated apoptosis<\/li>\n<\/ul>\n <\/div>[divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-3″ animate=”yes” delay=”100″][\/vc_column_inner][vc_column_inner column_padding=”padding-4-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][split_line_heading animation_type=”line-reveal-by-space” font_style=”h4″ text_color=”#31a7b1″ line_reveal_by_space_text_effect=”default” stagger_animation=”true” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”Indirect Cytotoxicity
    \n<\/b>” max_width=”500″][\/split_line_heading][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-3″ animate=”yes” delay=”100″][divider line_type=”No Line” custom_height=”10px”][image_with_animation image_url=”6932″ image_size=”full” animation_type=”entrance” animation=”Fade In” animation_easing=”default” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”]
    \n
      \n
    • Tumor derived antigen cross-presentation of CD8\u03b1+ DC, stimulated by IFNb<\/li>\n
    • Activation of antigen-specific cytotoxic T-cell<\/li>\n
    • Tumor cell death<\/li>\n<\/ul>\n <\/div>[divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-3″ animate=”yes” delay=”100″][\/vc_column_inner][\/vc_row_inner][vc_column_text]\n

      Enhanced efficacy and reduced systemic toxicity<\/b><\/span><\/h4>\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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