{"id":6739,"date":"2022-04-28T15:33:53","date_gmt":"2022-04-28T06:33:53","guid":{"rendered":"https:\/\/abionbio.com\/?page_id=6739"},"modified":"2025-10-17T13:39:33","modified_gmt":"2025-10-17T04:39:33","slug":"abn101","status":"publish","type":"page","link":"https:\/\/abionbio.com\/en\/abn101\/","title":{"rendered":"ABN101"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#333333″ bg_image=”7279″ bg_position=”left top” background_image_loading=”default” bg_repeat=”no-repeat” video_bg=”use_video” background_video_loading=”default” scene_position=”center” top_padding=”10%” bottom_padding=”7%” text_color=”light” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” color_overlay=”#203864″ overlay_strength=”0.8″ gradient_direction=”top_to_bottom” shape_divider_position=”bottom” bg_image_animation=”none” parallax_bg=”true” parallax_bg_speed=”fast” video_mute=”true” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Next Generation Interferon-\u03b2<\/span>[\/vc_column_text][split_line_heading animation_type=”default”]\n

ABN101<\/h1>\n[\/split_line_heading][vc_column_text css=”.vc_custom_1684370305506{margin-top: -15px !important;}”]Broad Spectrum Prophylaxis
\nAnti-viral Inhaler therapeutics<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”20px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7371″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”default” hover_content=”BEST-IN-CLASS cMET TKI For NSCLC Patient” link_url=”\/en\/abn401\/” min_height=”250″ min_height_phone=”175″]\n

ABN401<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7366″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”default” hover_content=”Broad Spectrum Prophylaxis
\nAnti-viral Inhaler Therapeutics” link_url=”\/en\/abn101\/” min_height=”250″ min_height_phone=”175″]\n

ABN101<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7370″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”default” hover_content=”Pan-Carcinoma Target Drug” link_url=”\/en\/abn501\/” min_height=”250″ min_height_phone=”175″]\n

ABN501<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7368″ hover_color=”accent-color” hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”default” link_url=”\/en\/abn201\/” min_height=”250″ min_height_phone=”175″ hover_content=”Pioneering Antibody Cytokine Fusion Protein Platform”]\n

ABN201<\/strong><\/h3>\n[\/fancy_box][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”130PX” bottom_margin=”60PX” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][nectar_highlighted_text color_type=”regular” highlight_color=”#c2e3ea” style=”half_text” delay=”100″]\n

Prophylaxis Anti-viral Inhaler Therapeutics ABN101<\/b><\/em><\/span><\/h4>\n[\/nectar_highlighted_text][divider line_type=”No Line” custom_height=”30px”][image_with_animation image_url=”7164″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin=”80px” column_element_direction_desktop=”default” column_element_spacing=”default” centered_text=”true” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][divider line_type=”No Line” custom_height=”60px”][vc_column_text]\n

Summary<\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][nectar_highlighted_text color_type=”regular” style=”full_text” highlight_expansion=”default”]\n

ABION<\/b><\/em> is currently developing ABN101, a dry powder inhaler utilizing next-generation interferon-\u03b2, as a prophylactic treatment for various respiratory viruses.<\/p>\n

The primary objective driving the development of ABN101<\/b><\/em> is to provide early-stage patients with a preventive measure against severe viral infections, thereby reducing the probability of hospitalization and severity of illness. Additionally, the goal is to stockpile and distribute ABN101 during the initial phases of a pandemic, such as COVID-19, to mitigate casualties before a vaccine becomes widely available.<\/p>\n

ABN101<\/b><\/em> serves as a prophylactic inhaler, meticulously tailored to offer preventative care for at-risk individuals vulnerable to moderate or severe viral infections. Harnessing the heightened stability of interferon-\u03b2<\/b><\/em>, ABN101 triggers the innate immune response within cells, prompting them to activate the adaptive immune response. This dual immune mechanism provides robust protection against diverse respiratory viruses. Administering ABN101 preemptively during the early stages of viral infection proves highly effective, capitalizing on the body’s innate immune response to combat various respiratory virus strains.<\/p>\n

Traditional cytokines present considerable bioprocessing challenges due to their inherent instability. However, ABION’s groundbreaking advancement with ABN101 has significantly bolstered its stability, leading to heightened productivity. This newfound stability has facilitated the development of diverse ABN101 formulations, including a dry-powder variant. This dry-powder formulation can be seamlessly integrated with commonly used inhalers, particularly those utilized by asthma patients. Offering benefits such as straightforward storage, portability, and user-friendly administration, this dry-powder inhaler emerges as a highly accessible medical solution, particularly during pandemics or outbreaks of respiratory viruses.<\/p>\n

ABN101\u00a0<\/b><\/em>has demonstrated its effectiveness in inhibiting various COVID-19 variants and other viruses in cell lines. Presently, ABN101 is undergoing preclinical evaluation in animal models using an inhaler delivery system. Encouraged by the promising preclinical outcomes, we anticipate submitting an Investigational New Drug (IND) application in 2025, marking a significant step forward in ABN101’s progression towards clinical trials.<\/p>\n[\/nectar_highlighted_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” bottom_padding=”150px” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”80PX” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][vc_column_text]\n

Mechanism of Action<\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][nectar_highlighted_text color_type=”regular” highlight_color=”#c2e3ea” style=”half_text” delay=”100″]\n

ABN101<\/b><\/em> is a biopharmaceutical that utilizes both the innate and adaptive immune responses of cells<\/p>\n

to effectively suppress respiratory viruses in their early stages, thereby offering a preventive therapeutic effect.<\/p>\n[\/nectar_highlighted_text][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

What is Interferon<\/span>?<\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][image_with_animation image_url=”7165″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”60px”][nectar_highlighted_text color_type=”regular” style=”full_text” highlight_expansion=”default”]\n

Interferon,<\/b><\/em> a protein produced by immune cells, is part of the cytokine family responsible for orchestrating immune responses and signaling during foreign invasions. Type 1 interferons, such as interferon-alpha and interferon-beta, are frequently utilized as biopharmaceuticals. Interferon triggers innate immune responses within cells, hindering viral replication, and also prompts adaptive immune responses involving natural killer cells (NK cells), dendritic cells, T cells, and B cells to combat the infection.<\/p>\n

Interferon-beta<\/b><\/em>, produced by most viruses through this mechanism, has demonstrated significant promise as a preventive treatment when administered promptly after infection or at the early onset of symptoms. During the initial stages of the COVID-19 pandemic in 2019, it was prescribed as an off-label medication in the United States to alleviate symptoms in patients awaiting a definitive cure.<\/p>\n

However, bioprocessing natural interferon substances presents considerable challenges, resulting in high production costs that impede widespread administration, especially during the early phases of viral infections. Additionally, the limited formulation options restrict their suitability for non-hospitalized patients.[\/nectar_highlighted_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”No Line” custom_height=”130px”][vc_column_text]\n

With Enhanced<\/span>\u00a0Stability,
\nBringing Care Closer<\/span> to Patients <\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][vc_column_text]