{"id":6726,"date":"2022-04-28T14:49:28","date_gmt":"2022-04-28T05:49:28","guid":{"rendered":"https:\/\/abionbio.com\/?page_id=6726"},"modified":"2025-10-17T13:28:18","modified_gmt":"2025-10-17T04:28:18","slug":"abn401","status":"publish","type":"page","link":"https:\/\/abionbio.com\/en\/abn401\/","title":{"rendered":"ABN401"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#333333″ bg_image=”7279″ bg_position=”left top” background_image_loading=”default” bg_repeat=”no-repeat” video_bg=”use_video” background_video_loading=”default” scene_position=”center” top_padding=”10%” bottom_padding=”7%” text_color=”light” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” color_overlay=”#203864″ overlay_strength=”0.8″ gradient_direction=”top_to_bottom” shape_divider_position=”bottom” bg_image_animation=”none” parallax_bg=”true” parallax_bg_speed=”fast” video_mute=”true” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]C-MET Tyrosine Kinase Inhibitor<\/span>[\/vc_column_text][split_line_heading animation_type=”default”]\n

ABN401<\/h1>\n[\/split_line_heading][vc_column_text css=”.vc_custom_1684370224737{margin-top: -15px !important;}”]ABN401 Best-In-Class C-MET TKI For NSCLC Patient<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”20px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” video_bg=”use_video” background_video_loading=”default” scene_position=”center” top_padding=”3%” text_color=”light” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” video_mute=”true” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7366″ hover_color=”extra-color-2″ hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”BEST-IN-CLASS cMET TKI For NSCLC Patient” link_url=”\/en\/abn401\/” min_height=”250″ min_height_phone=”175″]\n

ABN401<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7369″ hover_color=”extra-color-2″ hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”Broad Spectrum Prophylaxis
\nAnti-viral Inhaler Therapeutics” link_url=”\/en\/abn101\/” min_height=”250″ min_height_phone=”175″]\n

ABN101<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7370″ hover_color=”extra-color-2″ hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”top” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” hover_content=”Pan-Carcinoma Target Drug” link_url=”\/en\/abn501\/” min_height=”250″ min_height_phone=”175″]\n

ABN501<\/strong><\/h3>\n[\/fancy_box][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”hover_desc” icon_family=”none” image_url=”7368″ hover_color=”extra-color-2″ hover_desc_color_opacity=”default” hover_desc_hover_overlay_opacity=”default” icon_position=”bottom” box_alignment=”center” hover_desc_bg_animation=”long_zoom” border_radius=”10px” image_loading=”lazy-load” link_url=”\/en\/abn401\/” min_height=”250″ min_height_phone=”175″ hover_content=”Pioneering Antibody Cytokine Fusion Protein Platform”]\n

ABN201<\/strong><\/h3>\n[\/fancy_box][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”80px” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][divider line_type=”No Line” custom_height=”30px”][nectar_highlighted_text color_type=”regular” style=”half_text”]\n

“BEST-In-CLASS c-MET TKI” ABN401<\/b><\/em><\/span><\/h4>\n[\/nectar_highlighted_text][divider line_type=”No Line” custom_height=”60px”][image_with_animation image_url=”7125″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”No Line” custom_height=”130px”][vc_column_text]\n

Summary<\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][nectar_highlighted_text color_type=”regular” style=”full_text” highlight_expansion=”default”]\n

ABN401<\/b><\/em> is an innovative tyrosine kinase inhibitor<\/b><\/em> specifically designed to target c-Met mutant cancers.<\/p>\n

The c-Met protein plays a crucial role in cancer cell growth and angiogenesis, making it an attractive target for therapeutic intervention. Mutations in c-Met have been observed in various cancer types, and recent research has highlighted the poor prognosis associated with these mutations. Notably, MET Exon 14 skipping mutations have been reported in approximately 3% of patients with non-small cell lung cancer (NSCLC). Moreover, recent research demonstrates that c-Met mutations are the predominant mechanisms of resistance to EGFR TKIs.<\/p>\n

In Phase 1 clinical trials, ABN401 has demonstrated exceptional safety profiles<\/b><\/em>. During a dose-escalation study, no grade 3 or higher adverse events were reported, indicating a favorable safety profile. Additionally, promising efficacy outcomes were observed, with two partial response noted during the Phase 1 trial. Building upon these encouraging results, ABN401 is currently advancing through Phase 2 clinical development, focusing on patients with MET exon 14 deletions in NSCLC. The objective is to provide a targeted therapy option that prioritizes patient safety.<\/p>\n

ABION announced in January 2023 that the first patient had been enrolled in the Phase 2 trial<\/b><\/em> for ABN401. This trial is currently ongoing and is registered under the National Clinical Trials (NCT05541822)<\/a> database. By evaluating the efficacy and safety of ABN401 in a larger patient population, this Phase 2 trial aims to further validate its therapeutic potential and bring us closer to offering an effective treatment option for NSCLC patients with MET exon 14 skipping mutation.<\/p>\n[\/nectar_highlighted_text][divider line_type=”No Line” custom_height=”140px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin=”90PX” bottom_margin=”150PX” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][vc_column_text]\n

Mechanism of Action<\/b><\/span><\/h4>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”60px”][nectar_highlighted_text color_type=”regular” style=”full_text” highlight_expansion=”default”]\n

ABN401<\/b><\/em>
\nbinds to the ATP binding site of the MET tyrosine kinase and inhibits the kinase activity.
\nABN401 targets MET mutation in NSCLC.[\/nectar_highlighted_text][divider line_type=”No Line” custom_height=”50px”][vc_column_text css=”.vc_custom_1760675248887{padding-bottom: 33px !important;}”]\n